调节性T细胞与肿瘤研究进展

摘要

CD4+CD25+regulatory T cells (Treg) is a subset with acknowledged specific function of inhibiting immune responses. CD4+CD25+regulatory T cells have been associated with prevention of antitumor immunity and the evasion of efficient recognition of tumor antigens. These T cells play critical roles in immunologic self-tolerance, antitumor immune responses, transplantation and so on. Treg cells could inhibit antitumor immunity. FOXP3 serves as an important regulator for the development and function of Treg cells. FOXP3 has emerged as a critical regulator of the development and function of CD4+CD25+ Treg cells. The regulatory effect of Treg cells is key in tumor immunotherapy.%CD4+CD25+调节性T细胞(regulatory T cells,Treg)是指一类具有免疫调节功能的T淋巴细胞,在维持机体免疫自稳、调控免疫应答方面起重要作用.近年研究表明,Treg细胞也可能通过相同的机制消弱机体的抗肿瘤效应.FOXP3是近年发现的影响Treg生物功能发挥的关键转录因子,是Treg表面特异性标志,是Treg发育和功能发挥的关键基因.综述Treg生物学特性及与肿瘤关系的研究进展.