年轻子宫内膜癌女性保留生育及卵巢功能的治疗进展

摘要

Endometrial carcinoma (EC) is one of the three common malignant tumor in female reproductive system. Young child-bearing female with endometrial carcinoma are respectively rare. However, with the increasing incidence of endometrial carcinoma and the changes of living habits, endometrial carcinoma shows the significantly young trend. The standard treatment programs of EC leads women to have permanent loss of fertility and premenopausal women advance into menopause,severely affecting the quality of life of young patients.So young EC women retain fertility preservation or ovarian preservation gradually taken attention.The current programs of fertility preservation include:progesterone,aromatase inhibitors, metformin and other medical treatment and hysteroscopic endometrial cancer resection. Several studies have confirmed that obesity was associated with the occurrence and development of endometrial carcinoma. Ovarian preservation and the weight management in period of treatment of young female with endometrial carcinoma are now discussed in this review.%子宫内膜癌(endometrial carcinoma,EC)是女性生殖系统三大恶性肿瘤之一,年轻育龄期EC患者相对少见,但随着子宫内膜癌发病率的逐渐上升,以及现代生活习惯的改变,EC出现明显年轻化趋势.EC的标准治疗方案使得女性永久性失去生育功能以及绝经前女性提前进入更年期,严重影响年轻患者的生活质量.故年轻EC患者保留生育功能或保留卵巢功能的治疗方案逐渐受到重视.现有的保留生育功能方案主要有:孕激素、芳香化酶抑制剂、二甲双胍等药物治疗以及宫腔镜下EC病灶切除术.多项研究已经证实,肥胖与EC发生发展相关,保留生育功能治疗期间体质量管理同样也至关重要.现就年轻EC女性保留生育及卵巢功能治疗以及治疗期间体质量管理等的研究进展进行综述.