三氯化铁催化的羟基亲核取代的碳碳键形成反应

摘要

三氯化铁能够有效地催化吲哚取代γ-羟基内酰胺中羟基形成新的C-C键。反应可能是通过N-酰亚胺离子历程进行。该反应能够在短时间内形成高产率的γ-取代内酰胺，反应条件温和，稳定性好，可规模放大。%An efficient FeCl3-catalyzed nucleophilic substitution reaction of γ-hydroxylactams with in⁃doles has been developed. The reaction proceeded through an intermediary N-acyliminium ion and provid⁃ed substituted γ-lactams in excellent yields and in a very short reaction time. Meanwhile, the reaction could be stably scaled up in the mild condition.