COPD 急性加重期和稳定期患者的肺功能评估及其与血清促炎因子、趋化因子的相关性

摘要

目的：：分析慢性阻塞性肺疾病(COPD)急性加重期和稳定期患者的肺功能评估及其与血清促炎因子、趋化因子的相关性.方法：87例 COPD 患者根据病情分为处于急性加重期的观察组患者32例、处于稳定期的对照组患者55例.对比两组患者的肺功能指标，血清促炎因子、趋化因子含量差异，进一步分析肺功能指标与血清促炎因子、趋化因子含量的相关关系.结果：观察组患者的 FEV1、FVC、FEV1/FVC、FEF75、PEF、IC 水平均显著低于对照组患者；血清促炎因子 IL-1β、IL-4、IL-18、IL-23、TNF-α、IFN-γ含量显著高于对照组患者；血清趋化因子 Eotaxin、MDC、FKN、MCP-1、CCL18、RAN-TES 含量均显著高于对照组患者.COPD 患者的 FEV1、FVC、FEV1/FVC 水平与促炎因子、趋化因子含量呈负相关关系.结论：COPD 急性加重期肺功能下降，促炎因子及趋化因子的含量变化均参与其中.%Objective:To analyze the lung function in patients with acute exacerbation and stable COPD and its correla-tion with serum proinflammatory factors and chemokines.Methods:A total of 87 patients with chronic obstructive pulmonary disease (COPD)were divided into observation group (n =32)at acute exacerbation phase and control group (n =55)at stable phase according to the illness.Differences in lung function indexes and serum levels of proinflammatory cytokines,chemokines were compared between two groups of patients,and the correlation between lung function indexes and serum levels of proin-flammatory cytokines and chemokines was further analyzed.Results:FEV1,FVC,FEV1/FVC,FEF75,PEF and IC levels of observation group were significantly lower than those of control group;serum proinflammatory cytokines IL-1β,IL-4,IL-18, IL-23,TNF-αand IFN-γ content were significantly higher than those of control group;serum chemokines Eotaxin,MDC, FKN,MCP-1,CCL18 and RANTES content were significantly higher than those of control group.FEV1,FVC and FEV1/FVC levels in patients with COPD were negatively correlated with the content of proinflammatory cytokines and chemokines. Conclusions:Lung function declines in acute exacerbation COPD,and the changes in levels of both proinflammatory cytokines and chemokines are involved in it.