雷公藤联合丹参治疗对紫癜性肾炎患儿肾功能、凝血功能、免疫应答的影响

摘要

Objective:To investigate the effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function,coagulation function and immune response in children with purpura nephritis.Methods:7O children with purpu-ra nephritis who were treated in the hospital between October 2O13 and March 2O17 were divided into control group(n=35) and Salvia Miltiorrhiza group(n=35)by random number table.Control group received routine + tripterygium wilfordii thera-py,Salvia Miltiorrhiza group received routine + tripterygium wilfordii + Salvia Miltiorrhiza therapy,and the therapies lasted for 3 courses.The differences in renal function,coagulation function and immune response were compared between the two groups before and after treatment.Results:Before treatment,there was no statistically significant difference in renal function, coagulation function and immune response function between the two groups.After 3 courses of treatment,renal function inde-xes CysC,β2MG and 24hUmAlb levels in Salvia Miltiorrhiza group were lower than those in control group;coagulation func-tion indexes FIB and D-D levels in peripheral blood were lower than those of control group;immune response indexes Th1 cyto-kines IL-2 and IFN-γ contents in peripheral blood were higher than those of control group whereas Th2 cytokines IL-5 and IL-1O contents were lower than those of control group.Conclusion:Tripterygium wilfordii combined with Salvia Miltiorrhiza ther-apy can effectively optimize the renal function,reduce the hypercoagulation state and reduce the Th1/Th2 immune imbalance in children with purpura nephritis.%目的:探讨雷公藤联合丹参治疗对紫癜性肾炎患儿肾功能、凝血功能、免疫应答的影响.方法:2O13年1O月~2O17年3月到本院就诊的紫癜性肾炎患儿7O例,经随机数表法分为对照组、丹参组各35例.对照组接受常规+雷公藤治疗,丹参组接受常规+雷公藤+丹参治疗,持续3疗程.对比两组患者治疗前后肾功能、凝血功能、免疫应答的差异.结果:治疗前,两组肾功能、凝血功能、免疫应答功能的差异无统计学意义.治疗3疗程后,丹参组肾功能指标CysC、β2MG、24hUmAlb的水平低于对照组;外周血凝血功能指标FIB、D-D的水平低于对照组;外周血免疫应答指标T h1细胞因子IL-2、IFN-γ的含量高于对照组,T h2细胞因子IL-5、IL-1O的含量低于对照组.结论:紫癜性肾炎患儿接受雷公藤联合丹参治疗可有效优化肾功能、降低机体高凝状态、减轻T h1/T h2免疫失衡程度.