Effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis

摘要

Objective: To investigate the effects of tripterygium wilfordii combined with SalviaMiltiorrhiza therapy on renal function, coagulation function and immune response in childrenwith purpura nephritis. Methods: A total of 70 children with purpura nephritis who weretreated in the hospital between October 2013 and March 2017 were divided into controlgroup (n=35) and Salvia Miltiorrhiza group (n=35) by random number table. Control groupreceived routine + tripterygium wilfordii therapy, Salvia Miltiorrhiza group received routine+ tripterygium wilfordii + Salvia Miltiorrhiza therapy, and the therapies lasted for 3 courses.The differences in renal function, coagulation function and immune response were comparedbetween the two groups before and after treatment. Results: Before treatment, there was nostatistically significant difference in renal function, coagulation function and immune responsefunction between the two groups. After 3 courses of treatment, renal function indexes CysC,β2MG and 24 h UmAlb levels in Salvia Miltiorrhiza group were lower than those in controlgroup; coagulation function indexes FIB and D-D levels in peripheral blood were lower thanthose of control group; immune response indexes Th1 cytokines IL-2 and IFN-γ contentsin peripheral blood were higher than those of control group whereas Th2 cytokines IL-5 andIL-10 contents were lower than those of control group. Conclusion: Tripterygium wilfordiicombined with Salvia Miltiorrhiza therapy can effectively optimize the renal function, reducethe hypercoagulation state and reduce the Th1/Th2 immune imbalance in children with purpuranephritis.