Synthetic polynucleotide vaccine against HIV infection and processes to induce immune responses in a vertebrate against epitopes of HIV responses against infection or disease caused by virulent strains of HIV anti-HIV immune responses in a primate and a cell presenting antigen to stimulate effector functions and proliferation of helper and cytotoxic t cells and to increase dna expression by conducting a hiv pretein or fragment thereof

摘要

Synthetic DNA molecules encoding HIV genes and modifications of HIV genes are provided. The codons of the synthetic molecules use codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through neutralizing antibody and cell-mediated immunity.