Synthetic polynucleotide, immune response method, immunogenic composition, anti-HIV immune response induction method, antigenic cell induction method and pharmaceutical composition

摘要

Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.