阿奇霉素序贯疗法联合痰热清对小儿支原体肺炎患者内在作用机制研究

摘要

目的:研究阿奇霉素序贯疗法联合痰热清对小儿支原体肺炎患者血清可溶性髓系细胞触发受体-1(sTREM-1)、肌酸激酶(CK)、粒细胞集落刺激因子(G-CSF)、白介素-10(IL-10)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平的影响,并探讨其作用机制.方法:选择我院收治的80例支原体肺炎患儿,随机分为对照组和治疗组各40例.对照组单纯给予阿奇霉素序贯疗法,治疗组给予阿奇霉素序贯疗法联合痰热清治疗,所有患儿均给予连续治疗2个疗程.检测并比较两组治疗前后血清sTREM-1、CK、G-CSF、IL-10、CRP及TNF-α水平.结果:两组血清sTREM-1、CK、G-CSF、IL-10、CRP及TNF-α的治疗前水平比较,均无显著性差异(P>0.05);两组血清sTREM-1、CK、G-CSF、IL-10、CRP及TNF-α的治疗后水平相比于治疗前均明显偏低,并且治疗组血清sTREM-1、CK、G-CSF、IL-10、CRP及TNF-α水平下降明显大于对照组,差异均具有统计学意义(P<0.05).结论:阿奇霉素序贯疗法联合痰热清能够明显降低支原体肺炎患儿血清sTREM-1、CK、G-CSF及炎性因子水平,治疗效果显著,值得在临床上推广应用.%Objective:To study the effects of Azithromycin sequential therapy combined with Tanreqing injection on serum sTREM-1,CK,G-CSF,IL-10,CRP and TNF-α in children with mycoplasma pneumonia.Methods:A total of 80 children with mycoplasma pneumonia in our hospital from June 2014 to September 2016 were enrolled in this study.The subjects were divided into the control group (n=40) and the treatment group (n=40) randomly.The control group were treated with Azithromycin sequential therapy,the treatment group were treated with Azithromycin sequential therapy combined with Tanreqing injection.The two groups were treated for 2 periods.The serum sTREM-1,CK,G-CSF,IL-10,CRP and TNF-α levels of the two groups before and after treatment were compared.Results:There were no significantly differences in serum sTREM-1,CK,G-CSF,IL-10,CRP and TNF-α levels of the two groups before treatment (P>0.05).The serum sTREM-1,CK,G-CSF,IL-10,CRP and TNF-α levels of the two groups after treatment were significantly lower than before treatment (P<0.05),and that of the treatment group were significantly lower than the control group (P<0.05).Conclusion:Azithromycin sequential therapy combined with Tanreqing injection can significantly reduce the serum sTREM-1,CK,G-CSF,IL-10,CRP and TNF-αlevels of children with mycoplasma pneumonia,have good clinical efficacy,and it was worthy clinical application.