在前期合成并表征了可控降解抗感染材料环丙沙星聚氨酯（CFPU）的基础上,建立高效液相色谱法（HPLC）测定其体外降解释放抗菌药物环丙沙星的含量;通过制作累积药物释放曲线,考察不同降解介质及其浓度对药物释放的影响;并对累积药物释放曲线进行拟合,研究其体外可控降解的药物释放机制。结果表明建立的HPLC法简单准确可靠。该材料的降解具有生物响应性,且符合一级动力学;药物释放是以Ritger-Pappas方程（0.45%Based on the preparation and characterization of controlled release antibacterial material-ciprofloxacin-polyurethanes（CFPU）,the method of HPLC was established to determine the content of antibacterial agent-ciprofloxacin（CF） in the degradation solution of CFPU and investigate the drug-release mechanism in vitro by plotting and fitting the cumulative release curves to inspect the effects of different medium and different concentrations on drug release.The results showed that the HPLC method is accurate,reliable and simple.The drug-release of CFPU was bioresponsive and could be accorded with first order kinetics.It was observed that CF was released from CFPU by a combination of diffusion and erosion mechanism by modeling in the Ritger-Pappas equation（0.45n0.89）,mainly in the manner of diffusion in the absence of infection while erosion mechanism in the presence of infection.And the worse the inflammation was,the more erosion mechanism dominated.
展开▼
