大鼠甲醇中毒后视网膜电图振荡电位的变化

摘要

目的：研究大鼠甲醇中毒后视网膜电图（electroretinogram，ERG）振荡电位（oscillatory potentials， OPs）的变化特点。方法建立对照组及甲醇中毒3 d组、中毒7 d组的SD大鼠模型，在相应时间点于暗室内进行ERG检测，记录OPs波形特点。结果相对于对照组，中毒3 d组和中毒7 d组的总振幅均下降了约50%，时程分别延长约16%和61%。结论大鼠甲醇中毒后，ERG的OPs呈现时程延长、总振幅下降特点。%Objective To study the characters of oscillatory potentials (OPs) of electroretinogram (ERG) after methanol intoxication in rats. Method The SD rat models of methanol intoxication were established and divided into control group, 3-day intoxication group, 7-day intoxication group. The changes of OPs of ERG were recorded in a dark room. Results The total amplitudes of 3-day and 7-day intoxication groups decreased approximately 50% compared with that of the control group, while the schedule de-layed approximately 16% and 61%, respectively. Conclusion The characters of methanol intoxication in rats included delay in schedule and decline in the total amplitude of OPs.