双重抗炎功能超分子水凝胶的构建及其形貌、性质和性能

摘要

用经β-环糊精修饰的壳聚糖为主体大分子、抗炎药物布洛芬修饰的葡聚糖为客体大分子，制备得到具有双重抗炎功能的超分子水凝胶。扫描电子显微镜观测表明，水凝胶具有均一的孔洞结构。药物布洛芬可在酯酶的作用下快速释放，而在无酯酶存在时稳定保存于水凝胶中。并且，这一水凝胶具有良好的抗菌及抗炎作用，对于临床外伤修复具有潜在的应用价值。%A supramolecular hydrogel with dual function of anti-inflammation activities was prepared from chitosan-β-cyclodextrin and dextranmodified with a nonsteroidal anti-inflammatory drug (ibuprofen) self-assembled via a guest-host inclusion interaction. The hydrogel with uniform porous structure was observed under scanning electron microscope. Ibuprofen could be quickly released with esterase added and stays stable without esterase. In addition, the hydrogel has great potential of clinical application in wound healing since it possesses efficient anti- microbial and anti-inflammation activities.