超高效液相色谱-串联质谱法测定食品包装材料中双酚S含量

摘要

目的：建立一种食品包装材料中双酚 S 含量的检测方法。方法通过考察不同的提取方式、提取溶剂和提取温度,最后采用甲醇对食品包装材料进行超声提取,并将提取液过滤膜后直接进行超高效液相色谱-串联三重四极杆质谱分析；通过优化色谱-质谱仪器参数,最终采用多反应模式(MRM)进行定量检测。结果该方法检出限为0.10 mg/kg,定量限为0.30 mg/kg,在0.50~20 mg/kg范围内线性良好(相关系数为0.9993)。通过对空白样品进行双酚 S 的加标回收实验,结果表明平均回收率为89.6%~95.1%,相对标准偏差为3.1%~7.9%。结论该方法灵敏度高、抗干扰性强、重现性好,可用于常见食品包装材料中双酚S的含量检测。%Objective To establish a method for the determination of bisphenol S in food contact mate-rials.Methods By investigating different extract methods, solvents and temperature, methanol was chosen for the ultrasonic wave extraction of bisphenol S in food contact materials and then being determined by ultra per-formance liquid chromatography-tandem mass spectrometry after filtration. The quantitative detection of bis-phenol S was finnally employed by multi-reaction monitoring (MRM) mode after the optimization of the chromatogrph and mass spectrometric parameters.Results After the optimization of the chromatography and mass spectrum parameter, the LOD of this method was up to 0.10 mg/kg and the LOQ was 0.30 mg/kg. The correlation coefficient in the range of 0.50~20 mg/kg was 0.9993. The results spiked food contact materials showed that the average recoveries ranged from 89.6% to 95.1% while RSD ranged from 3.1% to 7.9%.Con-clusion This method, of high sensitivity and reproducibility, is applicable for the precise determination of bisphenol S in the routine food contact materials.