本研究通过检测外周血转化生长因子( TGF-β1)及其受体((TGF-βR)的表达探讨其在免疫性血小板减少性紫癜症(ITP)发病中的作用机制.以ITP患者为研究对象,健康人为对照,通过实时PCR方法检测外周血中TGF-β1及其受体(TGF-βRⅠ、TGF-βRⅡ和TGF-βRⅢ)的表达量,分析两组之间的差异.结果表明,ITP患者组TGF-β1和TGF-βRⅡmRNA的表达明显高于正常对照组,差异有统计学意义,而TGF-βR Ⅰ mRNA的表达明显低于正常对照组,差异有统计学意义.TGF-βRⅢmRNA的表达在两组间无统计学差异.结论:TGF-β1及其受体TGF-βR Ⅰ和TGF-pRⅡ在ITP患者中表达异常,表明TGF-β1信号通路在ITP患者发病中可能具有一定的作用.%This study was purposed to detect the expression of transforming growth factor β1 (TGF-β1 ) and itsrnreceptors (TGF-pR) and to investigate their roles in pathogenesis of immune thrombocytopenic purpura (ITP). Thernexpressions of TGF-β1 and their receptors TGF-βR I , TGF-pR H and TGF-pR i in the peripheral blood of patientsrnwith FTP and healthy persons were detected by the real-time PCR, and differences of their expression levels werernanalysed. The results showed that the expression of TGF-&1 and TGF-βR II mRNA in ITP patients was significantlyrnhigher than that in the healthy controls, while the TGF-pR I mRNA expression in ITP patient was significantly lowerrnthan that in the controls. The expression of TGF-βR HI was not statistically different between the two groups. It isrnconcluded that TGF-βl and its receptors including TGF-pR I and TGF-βR II express abnormally in the peripheral bloodrnof ITP patients, which suggests that the TGF-p signaling pathway probably play a vital role in the pathogenesis of thernITP.
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