多发性骨髓瘤侧群细胞的研究进展

摘要

侧群细胞具有高致瘤性、自我更新、多向分化和耐药的潜能.这些特性与肿瘤干细胞相似,因此侧群细胞渐渐成为研究肿瘤干细胞的切入点,为进一步研究肿瘤干细胞的生物学功能和分子机制奠定了基础.多发性骨髓瘤(multiple myeloma,MM)病人及其细胞系中均可以检测到侧群细胞,通过流式细胞仪加以分选,对其致瘤性,细胞周期,分化潜能,表面标记和耐药性进行了研究,更深入地了解多发性骨髓瘤的发病机制,并应用于临床早期诊断,为深入研究多发性骨髓瘤的治疗手段提供新的思路.本文将就多发性骨髓瘤侧群细胞的研究进展进行总结.%Side population cells have nigh tumorigenicity,self-renewal,and multi-directional differentiation potential,as well as chemotherapy resistance.All these characterristics of side population cells are similar to that of the tumor stem cells,so the side population cells gradually have become the point of penetration for the study of tumor stem cells,thus to lay a foundation to further explore the biological function and molecular mechanism of tumor stem cells.The patients with multiple myeloma and almost all MM cell lines were detected in the side population cells.The tumorigenicity,cell cycle,differentiation potential,surface markers and drug resistance of side population cells were studied by cell sorting with flow cytometry.The pathogenesis of multiple myeloma,and application to clinical diagnosis at the early stage all were understood deeply,so as to provide new ideas for further research on treatment.In this review,the research progress of side population cells in multiple myeloma is briefly summarized.