Histopathological and clinic observations of skin ulcers disease was conducted by conventional paraffin section preparation method in koi carp Cyprinus carpio koi cultured in ponds ( No. 1 and No. 2 ) from Shanghai Chaoyang koi carp farms. The results showed that the typical lesions in ulcers were found including a large number of congestion, inflammatory cell infiltration, inflammation, degeneration and necrosis in muscle bundles. These pathological features were caused by local infection of the ulcer bacteria, without infection on the whole body. There were highly consistent pathological changes including vasodilation, blood wall thickening, peripheral paren-chymal tissue, coagulation and degeneration in all samples. Some red blood cell necrosis was found in yellow bub-ble-shaped and degeneration area and coagulation necrosis deterioration was observed in splenic tissue, indicating that obvious lesions of spleen were caused by toxic substances in the blood, hematopoiesis and blood storage capa-bilities. Pathological changes were found to be less in hepatopancreas and kidney than those in the spleen, with normal intestines, heart, gills, head-kidney and other tissues. In summary, spleen solidification degeneration, hepatopancreas tissue congestion, congestion and renal interstitial tissue vasodilatation, and blood wall thickening were the same pathological changes in all samples, which were not involved in skin ulcer disease.%为临床诊断和防治锦鲤Cyprinus carpio koi皮肤溃疡病,采用病理解剖方法对患病锦鲤进行临床观察和组织病理学分析,试验用患病锦鲤取自上海市朝阳锦鲤养殖场发病池塘,确定病鱼10尾(编号1~10),取每条病鱼的组织进行病理解剖、石蜡切片、 H-E染色。结果表明：患病锦鲤体表溃疡病处的病灶组织出现严重淤血、炎性细胞浸润并聚集、肌束溶解和坏死等典型病理表现；体表溃疡病是由致病菌局部感染所致,并未全身性感染,10尾病料的脾组织均表现出血管扩张、管壁增厚、血管周围的实质组织凝固变性,伴有红细胞坏死和凝固变性区域内部分组织坏死等较为一致的病理特征,可以诊断为血液中有毒物质引起的脾组织病变,导致脾功能低下；肝胰组织和肾组织较脾组织病变相对较轻；肠、心、鳃、头肾组织等基本正常。研究表明,本病例全部样品均有不同程度的脾凝固变性、肝组织淤血、肾组织间质充血及其组织中血管扩张、管壁增厚的病理变化,这与体表溃疡病变无直接关联。
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