目的 探讨幽门螺杆菌(Hp)感染与自身免疫性甲状腺炎(AT)的相关性.方法 选取126名AT患者,将AT患者根据甲状腺功能分为A组(甲状腺功能正常)、B组(甲状腺功能亢进)、C组(甲状腺功能减退),100名与之匹配的对照者(D组).用免疫酶法测定各组的抗甲状腺过氧化物酶抗体(TPOAb)和抗甲状腺球蛋白抗体(TgAb),用ELISA方法检测各组的抗Hp抗体IgG和IgA.结果 A、B、C、D4组的Hp感染阳性率分别为71.4％、80％、83.3％和43％.A、B、C3组均比对照组有更高的Hp感染阳性率,而A、B、C3组间Hp感染阳性率差异无显著性意义；在AT患者中发现抗Hp抗体与甲状腺自身抗体呈正相关.结论 Hp感染与AT相关,可能是AT的病因之一.%Objective To research the relativity of Hp infection and AT. Methods 126 AT patients were chosen and divided into group A (normal thyroid function) , group B ( hyperthyroidism) , and group C ( hypothyroidism) according to thyroid function. 100 persons were chosen as control group( group D) , who were matching with AT patients. The levels of TPOAb, TgAb were detected by immunoenzyme method, anti - Hp antibody IgG and anti - Hp antibody IgA in respective group were detected by ELISA method. Results The positive rate of Hp infection in A, B, C, D group was respectively 71.4% , 80% , 83.3% and 43%. The positive rate of Hp infection was higher in A, B, C group than in control group. Nevertheless, there were no significant differences among A, B, C group. It was found that anti - Hp antibody is positively correlated with thyroid autoantibody in AT patients. Conclusion Hp infection is relative with AT, it may be one of the causes of AT.
展开▼
