微乳头型膀胱尿路上皮癌临床病理分析

摘要

目的探讨微乳头型膀胱尿路上皮癌的临床病理特征、诊断及鉴别诊断。方法回顾性分析1例微乳头型膀胱尿路上皮癌患者临床资料,通过光镜观察及免疫组化检测对其进行形态学观察和免疫表型定位。结果瘤细胞呈显著的微乳头方式生长,细胞卵圆形或不规则形,胞质丰富、嗜酸性或透明,核染色质分布不规则、核仁明显。瘤细胞弥漫浸润膀胱全层。免疫组化显示,CK7、CK20强阳性,p63、p53、cyclinD1阳性。结论微乳头型膀胱尿路上皮癌罕见,需与其他原发及继发膀胱肿瘤相鉴别,光镜观察及免疫组化有助于鉴别诊断。%Objective To study clinicopathologic features,diagnosis and differential diagnosis of micropapillary variant urothelial carcinoma of bladder. Methods Retrospectively analyze the clinical data of one rare case patient with micropapillary variant urothelial carcinoma of bladder admitted in Pudong New Area Zhoupu Hospital and H-E stained sections were examined and immunohistochemical staining was per-formed. Results The tumor cells exhibited siginicant growth of in a micropapillary manner.Cells were oval or irregular with abundant eosinophilic or transparent cytoplasm ,irregular distribution of chromatin and clear nucleolus.The tumor cells diffusely infiltrated the bladder.Immunohistochemically,there were strongly positive reactions for CK7,CK20 and positive reactions for P63,P53,cyclinD1. Conclusions Micropapillary variant urothelial carcinoma of bladder occurred rarely and shoud be differentiated from other primary and secondary bladder tumors.Microscope examination and immunohistochemis-try may be helpful in the differential diagnosis.