降钙素原指导下的抗生素应用与标准抗生素应用对于胸外科术后肺部感染预后的比较

摘要

[目的]比较降钙素原指导下的抗生素应用与标准抗生素应用对于胸外科术后肺部感染预后的影响.[方法]观察与分析了60例使用了同类抗生素胸外科术后并发肺部感染的患者在降钙素原指导下的抗生素应用与标准抗生素应用对感染治疗的结果.其中28例患者在使用抗生素后每日抽血化验降钙素原水平,在降钙素原恢复正常(小于0.5 ng/mL)后停用抗生素.其余32例患者使用抗生素后依据传统标准停用抗生素.比较两组患者的肺部感染的治疗结果及预后情况及抗生素使用天数.[结果]降钙素原指导组与传统标准组对于肺部感染治疗效果比较不存在统计学意义(P＞0.05),且降钙素原指导组抗生素使用天数短于传统标准组并存在统计学意义(P<0.05).[结论]对于胸外科术后肺部感染在降钙素原指导下的抗生素应用要优于标准抗生素应用.%[Objective]To compare the effect of procalcitonin- guided antibiotic usage vs standard antibiotic usage on the prognosis of pulmonary infection after thoracic surgery. [Methods]The results of 60 patients with lung infection after thoracic surgery who received procalcitonin- guided antibiotic usage or standard antibiotic usage were observed and analyzed. Blood samples of 28 patients in all patients were collected to detect the level of procalcitonin. The antibiotics were ceased when the level of procalcitonin was normal(＜0.5ng/mL). The other 32 patients stopped using antibiotics according to traditional standard. The treatment outcome, prognosis and the duration of antibiotic usage were compared between two groups. [Results] There was no significant difference in the efficacy of the treatment of lung infection between procalcitonin-guided group and standard group( P ＞0. 05). The duration of antibiotic usage in procalcitonin-guided group was shorter than that in standard group, and the difference had statistical significance( P ＜0.05). [Conclusion] Procalcitonin-guided antibiotic usage for lung infection after thoracic surgery is better than standard antibiotic usage.