[Objective] To explore the clinicopathological characteristics of patients with colorectal cancer with differ ent age. [Methods] Clinical data of 52 young patients(≤35 years old) diagnosed as colorectal cancer from Jan. 2003 to Dec. 2006 were analyzed retrospectively. Meanwhile 52 middle and old patients with colorectal cancer were randomly col lected for the contrast analysis. [Results] The patients with unhealthy lifestyle in young group were obviously higher than those in middle and old age group( P ＜0. 01). The main clinical manifestations were blood stool and the change of bowel habits in both groups. The major lesion site was rectum. The incidence of blood stool and abdominal pain in young group was significantly higher than that in middle and old age group( P ＜0. 01). The patients with poorly differentiated adeno carcinoma, mucinous adenocarcinoma, signet ring cell carcinoma and TNM stage Ⅲ + Ⅳ were significantly higher than those in middle and old age group( P ＜0. 01), but there was no significant difference in misdiagnosis rate between two groups( P ＞0. 05). The 1 ,3 and 5 year survival rates of young group were significantly lower than those of middle and old age group( P ＜0. 01). [Conclusion] The young patients with colorectal cancer have atypical clinical features, high misdiagnosis rate, low differentiation, high malignancy and poor prognosis.%[目的]探讨不同年龄大肠癌患者的临床病理特征.[方法]回顾性分析2003年1月至2006年12月确诊的青年(≤35岁)大肠癌52例的临床病例资料,与同期随机抽取的52例中老年大肠癌进行对照分析.[结果]①青年组中有不良生活习惯者明显高于中老年组(P＜0.01);②两组患者均以便血及大便习惯改变为主要临床表现,病变部位都以直肠为主,但青年组便血、腹痛的发生率明显高于中老年组(P＜0.01);③青年组低分化腺癌、粘液腺癌、印戒细胞癌和TNM分期Ⅲ+Ⅳ期病例均明显高于中老年组(P＜0.01),但两组误诊率无显著差异性(P＞0.05);④青年组1、3、5年生存率明显低于中老年组(P＜0.01).[结论]青年大肠癌临床特点不典型,误诊率高,分化程度低、恶性程度高、预后差.
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