Objective To observe the clinical effect of high dose ambroxol in the treatment of radiation pneumonitis patients. Methods 108 patients were randomly divided into the test group and the control group, 54 ca-ses in each group. All patients were given ambroxol on the base of glucocorticoid and antibiotics. The dose of the con-trol group was 60 mg, twice a day, and the dose of the test group was 300 mg, twice a day. One treatment course was 2 weeks. The efficacy, signs and symptoms disappear time and Leicester Cough Questionnaire ( LCQ) of the two groups were compared. Results The total effective rate of the test group was 96. 3%, which was significantly higher than that of the control group (81. 5%, P<0. 05). The signs and symptoms disappear time was significantly shorter in the test group than in the control group. The LCQ score was significantly higher in the test group than in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion The clinical effect of high dose ambroxol for radiation pneumonitis patients is satisfactory and safe, which can pro-mote the recovery of patients and improve the patient's quality of life and fewer adverse reactions.%目的：观察大剂量盐酸氨溴索治疗放射性肺炎的临床疗效。方法108例放射性肺炎患者随机分为观察组和对照组各54例,两组均在糖皮质激素和抗生素治疗的基础上给予盐酸氨溴素,对照组剂量60 mg,每日2次；观察组剂量300 mg,每日2次；疗程2周。比较两组患者的疗效、症状体征消失时间和Leicester咳嗽问卷(LCQ)评分。结果观察组总有效率为96．3%,显著高于对照组的81．5%(P<0．05)；观察组患者的症状体征消失时间也明显少于对照组,观察组各项LCQ评分和总评分的改善也显著优于对照组。两组不良反应发生率比较无明显差别。结论大剂量盐酸氨溴索治疗放射性肺炎疗效显著,可以促进患者的恢复,改善患者的生活质量,且不良反应少,值得在临床推广。
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