Objective To estimate the value of soluble scavenger receptor ( sMR) on diagnosing sepsis and evaluating the severity of sepsis, and to compare the sensitivity/specificity between sMR and other infection index on the values of evaluating sepsis which are commonly used in clinics. Methods The study selected 66 sepsis patients (40 sepsis cases and 26 septic shock cases) and 18 control cases. Their serum were collected on the first days. The level of sMR in serum was detected by ELISA, and they were given Sequential Organ Failure Assessment ( SOFA) score and Acute Physiology and Chronic Health Evaluation II ( APACHEII) score. Data calculation and processing were carried out by SPSS 17. 0. Results The concentration of sMR in serum among the control group, the sepsis and septic shock group was statistically significant (P<0. 05). The levels of PCT and sMR in the sepsis group were higher than those in the control group. The area under the receiver operating characteristic curve ( AUROC) for the prediction of sepsis were 0. 881/0. 954 for PCT and sMR respectively. The level of PCT showed no difference in the septic shock group and the sepsis group (P>0. 05), but it showed significant differences in sMR, APACHE II and SOFA between the two groups ( P <0. 05 ) . The AUC for detection of septic shock were 0. 883/0. 910/0. 972 for sMR, APACHEII and SOFA. sMR could distinguish septic shock from sepsis (P<0. 05). Spearman rank correlation analysis showed sMR had a weak positive correlation with PCT (0. 20.05),而sMR的表达水平在两组间具有显著统计学意义(P<0.05).SO-FA评分和APACHE II评分在sepsis和sepsis shock间差异均具有显著统计学意义,绘制诊断septic shock的ROC曲线,ROC曲线下面积分别为:0.910/0.972.Spearman秩相关分析显示,在脓毒症患者中sMR同PCT呈弱正相关性(0.2展开▼
