川崎病患儿血清白介素-17的变化

摘要

Objectives To explore the change of interleukin-17 (IL-17) in Kawasaki disease (KD). Methods Fourty KD pediatric patients, among them 12 patients with echocardiographic abnormalities in acute phase, 25 age-matched non-KD patients were enrolled. The level of serum IL-17 was measured by enzyme linked immunosorbent assay in acute and convalescent phase of KD patients and non-KD patients. At the same time, C-reactive protein (CRP), globulin, albumin were detected. Results In acute phase of KD patients, the level of serum IL-17 were signiifcantly higher than that in convalescent phase of KD patients and non-KD patients (P<0.05). The level of serum IL-17 was no signiifcant differences in convalescent phase of KD patients and non-KD patients (P>0.05). In acute phase of KD patients with echocardiography abnormalities, the level of serum IL-17 was signiifcantly higher than that with non-echocardiography abnormalities (P<0.05). The level of serum IL-17 in acute phase of KD patients were positively correlated with CRP and globulin (r=0.750, 0.750, P<0.05), and negatively correlated with albumin (r=-0.779, P<0.05). Conclusions IL-17 may be involved in KD immune pathogenesis. Serum IL-17 is one of the activity index of KD, which associ-ated with cardiovascular damages.%　　目的探讨川崎病（KD）患儿白介素–17（IL-17）水平变化的临床意义。方法收集KD患儿40例，其中12例急性期有超声心动图异常；另选年龄匹配的非KD患儿25例。采用双抗体夹心酶联免疫吸附法检测KD患儿急性期、恢复期及非KD患儿的血清IL-17水平，同时检测C反应蛋白（CRP）、球蛋白、白蛋白。结果 KD患儿急性期血清IL-17水平明显高于恢复期及非KD患儿，差异有统计学意义（P<0.05）；KD患儿恢复期血清IL-17水平与非KD患儿差异无统计学意义（P>0.05）；急性期超声心动图异常KD患儿的血清IL-17水平高于超声心动图正常的患儿，差异有统计学意义（P<0.05）。KD患儿急性期血清IL-17与CRP、球蛋白水平呈正相关（r=0.750、0.750，P均<0.05），而与白蛋白水平呈负相关（r=－0.779， P<0.05）。结论 IL-17参与KD的免疫损伤过程，血清IL-17水平是KD活动的指标之一，IL-17水平与心血管损害相关。