N末端B型钠尿肽原和肌酸激酶同工酶MB对肺炎患儿心力衰竭的诊断价值

摘要

ObjectiveTo investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and MB isoenzyme of creatine kinase (CK-MB) for heart failure (HF) in pneumonia children.MethodsThe NT-proBNP and CK-MB were assayed in 132 pneumonia children with HF, 138 pneumonia children without HF and 62 healthy children were recruited into this study. A receiver operating characteristics (ROC) curve and a logistic regression model were employed to assess the diagnostic accuracy of NT-proBNP and CK-MB for HF in pneumonia children.ResultsPneumonia children with HF had higher blood NT-proBNP and CK-MB than those in pneumonia children without HF and healthy controls (P<0.01 for both). Pneumonia children with HF had higher blood NT-proBNP and CK-MB than the pneumonia children without HF. The area under curves (AUCs) of NT-proBNP and CK-MB for HF were 0.85 and 0.72, respectively. The AUC for their combinational usage was 0.87.ConclusionBoth NT-proBNP and CK-MB are effective markers as diagnostic adjuncts for HF in pneumonia children. Combination of NT-proBNP and CK-MB can improve the diagnostic accuracy for HF in pneumonia children.%目的：评价N末端B型钠尿肽原(NT-proBNP)和肌酸激酶同工酶MB(CK-MB)诊断肺炎患儿心力衰竭的价值。方法检测132例肺炎合并心力衰竭、138例肺炎未合并心力衰竭患儿和61例健康儿童的血清NT-proBNP和CK-MB水平。以受试者工作特征(ROC)曲线分析法和logistic回归分析评价NT-proBNP和CK-MB对诊断肺炎患儿心力衰竭的价值。结果三组间血清NT-proBNP和CK-MB水平差异有统计学意义(P<0.01)；肺炎合并心力衰竭患儿最高，其次为肺炎未合并心力衰竭患儿，三组间两两比较差异均有统计学意义(P均<0.01)。血清NT-proBNP和CK-MB在肺炎患儿中诊断心力衰竭的曲线下面积分别为0.85和0.72，两者联合诊断的曲线下面积为0.87。结论在肺炎患儿中，血清NT-proBNP和CK-MB可以作为辅助诊断心力衰竭的指标。