比较奥卡西平或拉莫三嗪联合丙戊酸钠治疗脑外伤术后癫(癎)复发疗效

摘要

Objective To compare the effect of Oxcarbazepine or lamotrigine joint treatment on traumatic epilepsy relapse after Valproic acid given alone. Methods 3 months before the combine treatment of seizure frequency was as the control, and after 12 months of joint treatment, the efficacy, adverse effects and safety was compared respectively. Results After application of Oxcarbazepine or Lamotrigine combined Valproic acid treatment for 12 months, the patient' s seizure frequency decreased significantly compared with before. Seizure frequency reduction of > 50% of patients reached 89.2% and 89.7% separately,and statistically significant difference was observed before and after joint treatment ( P < 0. 05 ). There was also significant difference between two groups of Oxcarbazepine or Lamotrigine combined Valproic acid treatment (P < 0. 05 ). The adverse events of Oxcarbazepine combined Valproic acid treatment was 19. 3% , while Lamotrigine combined Valproic acid treatment adverse events was 9.1%, difference was significant. Conclusion Oxcarbazepine or Lamotrigine combined Valproic acid treatment of traumatic epilepsy recurrence is effective, and the side effects of combination of Lamotrigine and Valproic acid was lighter.%目的 探讨丙戊酸钠治疗脑外伤术后癫(癎)复发后,添加奥卡西平或拉莫三嗪联合治疗外伤性癫(癎)效果.方法 以治疗前3个月癫(癎)发作频度为对照,对治疗12个月后的疗效、不良反应及安全性进行自身对比观察.结果 应用奥卡西平或拉莫三嗪联合丙戊酸钠治疗12个月后,患者发作频率均较用药前明显减少；发作频率减少≥50％的患者分别为89.2％和89.7％,用药前后差异无统计学意义(P＜0.05)；奥卡西平或拉莫三嗪联合丙戊酸钠两组间差无明显统计学意义(P＞0.05).奥卡西平联合丙戊酸钠不良反应的发生率为19.3％,拉莫三嗪联合丙戊酸钠不良反应的发生率为9.1％,差异显著(P＜0.05).结论 奥卡西平或拉莫三嗪联合丙戊酸钠治疗外伤性癫(癎)复发疗效确切,副作用拉莫三嗪组明显低于奥卡西平组.