非酒精性脂肪肝患者载脂蛋白B及尿酸水平检测结果分析

摘要

目的 分析非酒精性脂肪肝(NAFLD)患者载脂蛋白B(ApoB)、血清尿酸(SUA)水平的检测结果.方法 将本院收治的150例NAFLD患者纳入研究组,将同期收治的150例体检检查健康人员作为对照组.检测2组患者低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、腰臀比(WHR)、体质量指数(BMI)、总胆固醇(TC)、ApoB、肌酐(Cr)、血清尿酸(SUA)水平.采用多元Logistic回归分析法分析SUA、ApoB与NAFLD相关性.同时,对2组患者吸烟、冠心病、糖尿病、高血压发生情况进行比较.结果 研究组LDL-C、TG、ALT、WHR、TC、BMI、SUA、ApoB水平均比对照组高,差异有统计学意义(P ＜0.05);研究组Cr水平显著低于对照组,差异有统计学意义(P ＜0.05);多元Logistic回归分析结果显示,SUA、ApoB水平呈独立正相关,是NAFLD的独立危险因素;研究组吸烟、冠心病、糖尿病、高血压发生率显著高于对照组,差异有统计学意义(P ＜0.05).结论 SUA、ApoB水平与NAFLD病情呈正相关,SUA、Apo B水平越高者心血管疾病发生率越高.因此确诊后应及时进行血脂干预,控制病情.%Objective To analyze the detection results of apolipoprotein B (ApoB) and serum uric acid (SUA) in patients with non-alcoholic fatty liver disease (NAFLD). Methods A total of150 NAFLD patients admitted to our hospital were selected as study group, and 150 healthy people with physical examination in the same period were as the control group. Low density lipoprotein cholesterol (LDL-C), triglyceride (TG), alanine aminotransferase (ALT), waist-hip ratio (WHR), body mass index (BMI), total cholesterol (TC), ApoB, creatinine (Cr), SUA levels were measured in the two groups. The correlation between SUA, ApoB and NAFLD was analyzed by multiple Logistic regression analysis. At the same time, smoking, coronary heart disease, diabetes and hypertension were compared between the two groups. Results The levels of LDL-C, TG, ALT, WHR, TC, BMI, SUA and ApoB in the study group were higher than those in the control group (P ＜ 0. 05). The levels of Cr in the study group were significantly lower than those in the control group (P ＜ 0. 05). The results of multiple Logistic regression analysis showed that the levels of SUA and ApoB were independently and positively correlated with NAFLD and were independent risk factors for NAFLD. The incidences of smoking, coronary heart disease, diabetes mellitus and hypertension were significantly higher than that of the control group (P ＜ 0. 05). Conclusion The levels of SUA and ApoB are positively correlated with NAFLD. The higher the levels of SUA and ApoB are, the higher the incidence of cardiovascular disease is. Therefore, blood lipid intervention should be carried out in time to control the development of NAFLD.