舒芬太尼或瑞芬太尼复合丙泊酚用于人工流产术麻醉效果比较

摘要

Objective To observe the anesthetic effect of sufentanil or remifentanil combined with propofol on induced abortion and explore the optimal combination of anesthetic drugs for induced abortion. Methods A total of 200 healthy early pregnant women for induced abortion were equally randomized into two groups. Sufentanil group (group S) was administered with sufentanil combined with propofol. Remifentanil group (group R) was administered with remifentanil together with propofol. Changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and oxygen saturation (SpO2) and intraoperative and postoperative analgesic effects were observed. Results All the patients were satisfied with the analgesia, especially die group S after the treatment. Postoperative VAS scores were lower in the group S than in the group R. SBP, DBP, MAP, HR, and SpQ2 were significantly decreased after the induction of anesthesia in both groups, whereas decrease of SpQ2 was more significant in the group R. Conclusion Compared with remifentanil, sufentanil combined with propofol has better postoperative analgesic effect and less side effects such as respiratory depression, being a safe and effective analgesic option for induced abortion.%目的 观察舒芬太尼或瑞芬太尼复合丙泊酚对于人工流产术麻醉效果的比较,探求人工流产术最佳的麻醉药物组合.方法 选择行无痛人工流产术的健康早孕妇女200例,并将其随机分为2组,每组100例.舒芬太尼组(S组):舒芬太尼复合丙泊酚；瑞芬太尼组(R组):瑞芬太尼复合丙泊酚.观察2组麻醉方法在人工流产术麻醉过程中不同点对患者的收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)的变化情况,以及对术中、术后镇痛效果的影响.结果 2组患者均镇痛满意,但术后以S组为优,术后VAS评分S组较R组低.SBP、DBP、MAP、HR、SpO2较麻醉诱导前均有明显降低,其中R组中SpO2下降程度显著.结论 同瑞芬太尼相比,舒芬太尼复合丙泊酚术后镇痛作用强,呼吸抑制等副作用小,应用于人工流产有一定的优越性,是安全、有效的人工流产镇痛方法.