Objective To investigate the clinical effects of benazepril combined with metoprolol in the treatment of chronic heart failure (CHF). Methods One hundred and twenty-two patients with CHF were randomly divided into treatment group and control group, 61 cases in each group. Both groups received conventional therapy. Benazepril and metoprolol were administered in the treatment group. The heart rate variability (HRV), vascular endothelial diastolic function of brachial artery, plasma brain natriuretic peptide (BNP), six-minute walk trial (6MWT) distance and adverse reactions of patients in both groups were compared. Results After treatment, every indexes of HRV significantly increased, and the increased range of treatment group was obviously larger than that of control group. Both the inner diameter (D1) of brachial artery and its expanding percentage markedly amplified in the two groups during reactive hyperemia, and the amplified range of treatment group was conspicuously larger than that of control group. BNP in 2 groups significantly decreased, 6MWT distance notably prolonged, and the decreased range of BNP and prolonged range of 6MWT distance were larger than those of control group. All adverse reactions of treatment group were slight. Conclusion Based on conventional therapy, the application of benazepril combined with metoprolol in the treatment of CHF patients can markedly elevate HRV indexes, enhance vascular endothelial diastolic function, decrease plasma BNP level and prolong 6MWT. The adverse reactions are slighter, and patients can tolerate, which deserves to be popularized and further researched.%目的 探讨贝那普利联合美托洛尔治疗慢性心力衰竭(CHF)患者的临床疗效.方法 将122例CHF患者随机分为治疗组及对照组,每组61例.2组均给予常规治疗,治疗组在此基础上加用贝那普利及美托洛尔.比较2组患者心率变异性(HRV)、肱动脉血管内皮舒张功能、血浆脑钠肽(BNP)、6 min步行试验(6MWT)距离及不良反应.结果 2组治疗后HRV各指标均较治疗前显著升高,治疗组升高幅度显著大于对照组；2组治疗后反应性充血期间肱动脉内径及肱动脉内径扩张百分比均显著增大,治疗组增大幅度显著大于对照组；2组治疗后BNP显著下降,6MWT距离显著延长,治疗组BNP下降及6MWT距离延长幅度均大于对照组.治疗组不良反应均较轻微.结论 在常规治疗基础上,应用贝那普利联合美托洛尔治疗CHF患者可显著升高HRV指标,改善血管内皮舒张功能,降低血浆BNP水平,延长6MWT距离,且不良反应轻微,患者可耐受,值得推广和进一步研究.
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