肠源性内毒素血症在肝衰竭发生发展中的作用

摘要

Recent studies have found that endotoxin not only activates immune response,exacerbates liver injury,and induces liver failure, but also plays an important role in the development of hepatic encephalopathy,hepatorenal syndrome,spontaneous bacterial peritonitis,and other fatal complications.The recent progress in research on the pathogenesis of intestinal endotoxemia (IETM)and its impact on the devel-opment and progression of liver failure is reviewed and summarized.It is suggested that seeking effective methods to prevent and control IETM holds promise as the key to treating severe liver disease and liver failure successfully.%内毒素除了激活免疫反应，加重肝损伤和诱发肝衰竭之外，还可能与肝性脑病、肝肾综合征、自发性细菌性腹膜炎等多种致死性并发症的形成密切相关。归纳总结了肠源性内毒素血症（IETM）的形成机制及其在肝衰竭发生、发展过程中作用的最新研究进展，认为寻求预防和控制IETM的有效方法，是临床成功治疗严重肝病和肝衰竭的关键。