Role of Sox2 in Lung Cancer Initiation and Progression.

摘要

The purpose of the proposed research is to clarify the mechanism of Sox2-induced non-small cell lung cancer. The first aim involves investigating p63 as a direct target of Sox2 in tumor cells. The second aim investigates the tumor-initiating ability of proximal and distal respiratory epithelial cells when Sox2 is overexpressed. The third aim tests the hypothesis that strain- specific modifier genes affect the phenotype of mice inducibly overexpressing Sox2 in Scgb1a1-expressing cells. We have continued work on all three aims.