重症监护病房铜绿假单胞菌肺部感染患者的危险因素分析

摘要

Objective To determine risk factors for Pseudomonas aeruginosa(PA)pneumonia and associated mortality in ICU patients,in order to provide the reference for pneumonia control. Methods This study was a retrospective review of ICU patients with infectious diseases (102 PA infection,102 non - PA infection)treated from April 2008 to March 2012. The patients were divided into PA group and non - PA group. There were 86 pneumonia patients in PA group and 73 pneumonia patients in non - PA group. Univariate and multivariate logistic regres-sion analysis was performed to determine the risk factors for PA pneumonia. Results Age,APACHEII score,length of ICU stay,establishment of artificial airway and mechanical ventilation time were linked to PA pneumonia morbidity. Multi - drug resistance was linked to PA pneumonia mortality. Conclusion Advanced age,severe illness,prolonged ICU stay,and longer duration of mechanical ventilation are independent risk fac-tors for PA pneumonia. Multi - drug resistance is independent risk factor for death.%目的：分析重症监护病房（ICU）肺炎患者铜绿假单胞菌（PA）感染及死亡的危险因素，为临床控制肺炎患者 PA 感染提供依据。方法回顾性分析2008年4月1日至2012年3月31日入住 ICU 的 PA 感染患者102例，非 PA感染患者102例，PA 感染患者中肺炎患者86例，非 PA 感染患者中肺炎患者73例，采用单因素及多因素 Logistic 回归分析 PA 肺炎感染的危险因素。结果年龄、入 ICU 时 APACHEⅡ评分、住 ICU 天数、是否建立人工气道、呼吸机使用时间是 PA 肺炎发生的独立危险因素，是否多重耐药是 PA 肺炎死亡的独立危险因素。结论患者高龄、病情重、机械通气、住 ICU 及机械通气时间长是 ICU 患者 PA 感染的独立危险因素，多重耐药是 PA 肺炎患者死亡的独立危险因素。