Objective To investigate risk factors and drug - resistance of Pseudomonas aeruginosa infection in intensive care unit ( ICU) ,and provide reference for clinical prevention and treatment. Methods A retrospective analysis of clinical data of 198 patients with nosocomial infection in ICU from September 2009 to September 2011 was done. Results Pseudomonas aeruginosa infection was 53 patients in 198 patients with nosocomial infection. Logistic regression analysis revealed that mechanical ventilation (OR =3. 365,95% CI 1.408 -8.043) ,central venous cstheterization (OR =3. 591,95% CI 1.666 -7.739) ,COPD(OR =5. 728,95% CI 2.643 -12.424) were independent risk factors of Pseudomonas aeruginosa infection. The resistance rate of Imipenem was the lowest ( 17% ) . Conclusion Pseudomonas aeruginosa is common pathogen in ICU, and it is usually multidaug-resistance. The rational use of antibiotics and aseptic technique of invasive catheterization are important for prevention of Pseudomonas aeruginosa infection.%目的 探讨医院重症监护病房(ICU)铜绿假单胞菌感染的危险因素和耐药性.方法 对2009年9月至2011年9月入住ICU发生院内感染的198例患者临床资料进行统计分析.结果 198例院内感染病例中有53例为铜绿假单胞菌感染.多因素Logistic回归分析显示:机械通气(OR=3.365,95％ CI 1.408-8.043)、深静脉置管(OR=3.591,95％ CI 1.666-7.739)、慢性阻塞性肺疾病(COPD)(OR =5.728,95％ CI 2.643-12.424)是铜绿假单胞菌感染的独立高危因素.药敏结果显示对亚胺培安耐药率最低,为22.0％.结论 铜绿假单胞菌是ICU常见的致病菌.且多具有多重耐药性.
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