目的：探索非何杰金恶性淋巴瘤病人体内β-葡萄糖醛酸酶（β-glucuronidase，β-G）的变化规律。方法：采用酶联免疫吸附测定（enzyme-linked immunsorbent assay，ELISA）方法，免疫组织化学方法对13例非何杰金恶性淋巴瘤患者血清及瘤组织中β-G进行同步测定，并对其中3例进行了免疫电镜研究。结果：β-G在非何杰金恶性淋巴瘤患者血清及瘤组织中均呈明显表达，与对照组有显著性差异（P<0.01）。结论：对β-G进行机能学与形态学的联合检测，可能成为非何杰金恶性淋巴瘤诊断的辅助指标。%Objective: Our purpose was to explore the change regularity of β-glucuronidase (β-G) in body of patients with Non-Hodgkin malignant lymphoma. Methods: β-G was examined synchronously both in the serum and in the tumor tissue of 13 cases patient with Non-Hodgkin malignant lymphoma by using the method of enzymlinked immunsorbent assay (ELISA) and immunohistochemistry separately. Among them, 3 cases were studied by using the immuno electron microscopic technique. Results: β-G was highly expressed both in the serum and tumorous tissue in patients with non-Hodgkin malignant lymphoma and there was obviously difference as compared with the control group (P<0.01). Conclusion: The combined detection with functional and morphological methods to β-G, it may be assistant target to early discovery and early diagnosis of Non-Hodskin malignant lymphoma.
展开▼
