MONITORING THERAPY IN CANINE MALIGNANT LYMPHOMA AND LEUKEMIA WITH SERUM THYMIDINE KINASE 1 ACTIVITY - EVALUATION OF A NEW, FULLY AUTOMATED NON-RADIOMETRIC ASSAY

摘要

Thymidine kinase 1 (TK), which is involved in the synthesis of DNA precursors, is only expressed in S-G2 cells. Serum TK levels correlate to the proliferative activity of tumor disease. Determinations of TK levels have so far relied on radio enzyme assay (REA) and experimental ELISA methods, which have limited the clinical use of this biomarker, although recent studies in dogs with malignant lymphoma (ML) demonstrate its large potential.