Isolated nucleic acid molecule, isolated nucleic acid, vector, protein, antibody and antisera formed against a protein, diagnostic kit, processes to reduce coagulase-negative staph infection from a medical retention device, to treat an infection of coagulase-negative staphylococcus, to prevent a coagulase-negative staph infection in a patient, to induce an immune response and to identify compounds that inhibit coagulase-negative staphylococci

摘要

"NUCLEIC ACID MOLECULE ISOLATED, NUCLEIC ACID ISOLATED, VECTOR, PROTEIN, ANTIBODY AND ANTI-SERUMS AGAINST A PROTEIN, DIAGNOSTIC KIT, PROCESSES TO REDUCE THE INFECTION OF STEPHILOCOCCOS, A UNITABLE DISEASE OF NEGATIVE ACTION. OF COAGULASE-NEGATIVE STAPHILOCOCUS, TO PREVENT A COAGULASE-NEGATIVE STAPHILOCOCCO INFECTION IN A PATIENT, TO INDUCT AN IMMUNOLOGICAL RESPONSE AND TO IDENTIFY COMPOUNDS THAT INHIBIT COAGULASE-NEGATIVE STAFF. Isolated proteins, called SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided, which are useful in preventing and treating infection caused by coagulase-negative staphylococcal bacteria, such as S. epidermidis. The SdrF, SdrG and SdrH proteins are proteins associated with the cell wall, which specifically binds host proteins and which each have a highly conserved motif, of which the consensus sequence is TYTFTDYVD. Proteins, their antigenic parts and antibodies to SdrF, SdrG and SdrH, are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, proteins are advantageous because they can be used as vaccine components or their antibodies, and they can be administered to wounds or used to cover biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.