isolated polypeptide molecule; isolated nucleic acid molecule; vector or plasmid; host cell; antibody; fusion protein; method for stimulating a specific tb immunogenic response in an individual or for preventing or reducing the severity of disease caused by tb; method for monitoring the treatment of TB disease in an individual; method of diagnosing disease caused by TB in an individual; method of distinguishing between disease caused by TB and immunity to disease caused by TB in an individual; method for detection of m infection. tuberculosis in a biological sample; composition; Diagnostic kit for the presence or absence of infection by m. tuberculosis in a person; and pharmaceutical composition

摘要

ISOLATED POLYPEPTIDE MOLECULATION; ISOLATED NUCLEIC ACID MOLECULA; VECTOR OR PLASMIDE; HOST CELL; ANTIBODY; FUSION PROTEIN; Method for stimulating an immune response specifies TB in an individual or for preventing or reducing the severity of disease caused by TB; METHOD FOR MONITORING TREATMENT OF TB DISEASE IN AN INDIVIDUAL; DIAGNOSTIC METHOD OF DISEASE CAUSED BY TB IN. ONE INDIVIDUAL; METHOD OF DISTINCTION BETWEEN THE DISEASE CAUSED BY TB AND IMMUNITY THE DISEASE CAUSED BY THE INDIVIDUAL; METHOD FOR DETECTION OF M. TUBERCULOSIS INFECTION IN A BIOLOGICAL SAMPLE; Composition; KIT FOR DIAGNOSIS OF THE PRESENCE OR ABSENCE OF M. TUBERCULOSIS INFECTION IN A PERSON; AND PHARMACEUTICAL COMPOSITION. The present invention relates to isolated Tuberculosis (TB) antigens, which are useful in therapeutic and vaccine compositions for stimulating a specific TB immune response. Antigens are also useful in diagnostic assays to determine the presence of active TB in an individual. Accordingly, the present invention includes polypeptide molecules, nucleic acid molecules, vaccine compositions, diagnostic assays, and methods for diagnosing and monitoring the treatment of these TB antigens.