北京社区痛风患者代谢综合征患病率研究

摘要

Objective:To determine the prevalence of the metabolic syndrome among patients with gout in Beijing Longitudinal Study on Aging Ⅱ (BLSA Ⅱ)cohort in 2009,and to examine the association between metabolic syndrome and gout.Methods:Using data from 9770 participants aged 50 years and older in BLSAⅡ cohort,we estimated the prevalence of metabolic syndrome among patients with gout and examined the association between metabolic syndrome and gout using logistic regression.Results:The prevalence (95％ confidence interval [95％ CI]) of metabolic syndrome was 65.2％(59.5％～70.9％)among individuals with gout and 46.9％ (45.9％～47.9％)among individuals without gout.The unadjusted and age-and sex-adjusted odds ratios (95％ CI)of metabolic syndrome for individuals with gout were 2.12 (1.65～2.73) and 2.19 (1.69～2.84),respectively.The stratified prevalences of metabolic syndrome by major associated factors of gout(i.e,body mass index,hypertension and diabetes)increased substantially and significandy among individuals with gout.Conclusion:Our BLSA Ⅱ cohort suggested that the prevalence of the metabolic syndrome increased substantially in individuals with gout.%目的:对北京的部分社区中老年人(年龄≥50岁)进行痛风患者中代谢综合征患病率和相关因素的研究.方法:以2009年北京老龄化纵向研究Ⅱ(BLSAⅡ)为基础,根据国际糖尿病联盟(IDF)关于代谢综合征的诊断标准,调查社区中老年人痛风患者中代谢综合征的流行病学数据.结果:参与BLSAⅡ研究的中老年人为9770例,其中男3786例、女5984例.痛风患者中代谢综合征的患病率为65.2％(95％CI 59.5％～70.9％),而非痛风的对照中代谢综合征的患病率为46.9％(95％CI 45.9％～47.9％).经性别和年龄校正后,痛风患者中患代谢综合征的风险是对照的2.2倍(95％CI 1.7～2.8)；代谢综合征各组分和分层相关因素(体重指数、高血压和糖尿病)后代谢综合征与痛风密切相关.结论:BLSAⅡ研究结果显示代谢综合征的患病率在痛风中增高.