儿童分次注射IPV、Hib和DTaP疫苗与注射联合疫苗的对比分析

摘要

To compare the side effect of separately injection of inactivated polio vaccine(IPV), Haemophilus influenzae type B vaccine (Hib)and adsorption of acellular DTP vaccine (DTaP)with DTaP-IPV/Hib combined vaccine and explore the more reasonable and effective inoculation approach.Methods: A total of 600 healthy infants in the hospital were randomly divided into two groups according to the principle of voluntary participation.The Group 1 was immunized with IPV,Hib and DTaP seperately,while the Group 2 was injected DTaP-IPV/Hib combined vaccine.Adverse reactions within 48 hours after injection were followed-up of the two groups.Comparative analysis was carried out on the side effects of manifestation, degree and doses of the two groups.Results: There were no significant differences in side effects of manifestation, degree and doses of the two groups (all P>0.05).Conclusion:The combined vaccine DTaP-IPV/Hib is safe and effective.It simplifies the inoculation procedure and is recommended in vaccination.%目的:比较注射单剂吸附无细胞百白破联合疫苗(DTaP)、脊髓灰质炎灭活疫苗(IPV)及B型流感嗜血杆菌疫苗(Hib)与DTaP-IPV/Hib五联疫苗(简称五联疫苗)接种后的副反应,探求合理有效的疫苗接种方式.方法:在我院免疫接种的600例健康婴幼儿,按照监护人自愿原则分为2组,第1组分次注射DTaP、IPV和Hib,第2组注射五联疫苗,接种48h后随访2组婴幼儿副反应情况,并对2组副反应临床表现、强弱、接种针次与副反应的关系进行比较.结果:不同方式预防接种2组婴幼儿副反应临床表现强弱、接种针次与副反应之间均无显著性差异(均P＞0.05).结论:五联疫苗的副反应与常规单剂免疫接种相似,它简化了免疫程序,应推荐接种.