HIB CONJUGATE LOW-DOSE COMBINATION VACCINES Combination vaccines including antigens to immunize against diphtheria, tetanus, pertussis and Hib are known ("DTP-Hib" vaccines). The invention addresses the need for such low dose Hib antigen vaccines to reduce costs which do not require reconstitution in the field. Thus, the invention provides a combination vaccine comprising antigens to protect an individual against at least diphtheria, tetanus, pertussis and Hib, wherein: (a) the antigen to protect against Hib is a conjugate of a Hib capsular saccharide; (b) the concentration of Hib conjugate in the vaccine is 15 µg / ml; and (c) Hib conjugate was never lyophilized. The vaccines of the invention have been found to be safe and highly immunogenic.
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