低温光聚合制备可降解多孔支架及其性能

摘要

以聚己内酯二醇和聚乳酸二醇为原料,合成了端双键的聚己内酯二甲基丙烯酸酯(PCLDMA)和聚乳酸二丙甲基烯酸酯(PLADMA).通过低温光聚合诱导相分离制备可降解多孔支架.结果表明:溶剂含量越高,孔隙率越高,孔径尺寸也越大;冷却温度对孔隙率的影响不大,但孔的尺寸随着冷却温度的降低逐渐减小,冷却速率越快,孔隙率和孔径尺寸越小;PCLDMA的热稳定性高于PLADMA,多孔支架孔隙率越大溶胀度越大;两种材料在PBS溶液中较为稳定,体外降解缓慢;PLADMA支架抗压强度和弹性模量高,性脆;PCLDMA支架抗压强度和弹性模量低,但韧性好.%The double bond-terminated polycaprolactone dimethacrylate (PCLDMA)and the double-capped polylactic acid dipropyl methacrylate (PLADMA)were synthesized.The biodegradable porous scaffolds were prepared by low temperature photopolymerization induced phase separation.The results of scanning electron microscopy showed the higher the solvent content,the higher the porosity and the larger the pore size.The size of the pores decreases gradually as the cooling temperature decreases,the faster the cooling rate,the smaller the porosity and pore size.The thermal stability of PCLDMA por-ous scaffold was higher than that of PLADMA.Two kinds of materials in PBS solution were stable and slow degradation in vitro.The mechanical properties of PLADMA porous scaffold have high com-pressive strength and elastic modulus,and the brittleness of PCLDMA scaffold has low compressive strength and elastic modulus,but possessed good toughness and some deformation recovery.