芍药甘草汤对痛经患者血清IL-1β、TNF-α 及疼痛的影响

摘要

目的 探讨芍药甘草汤对痛经患者血清促炎细胞受体激动剂-β(IL-1β)、肿瘤坏死因子-α(TNF-α)和疼痛的影响.方法 选取我院2014年5月-2016年5月116例痛经患者进行治疗,根据治疗方法分为试验组和对照组,各58例.对照组采用常规药物治疗,试验组在对照组治疗基础上加入芍药甘草汤进行治疗,治疗4个月,观察2组临床症状、血清IL-1β、TNF-α 及疼痛评分.结果 试验组总有效率98.3%,明显高于对照组的79.3%(P<0.05);试验组血清IL-1β、TNF-α 水平明显优于对照组(P<0.05);试验组疼痛评分明显少于对照组(P<0.05).结论 芍药甘草汤治疗痛经可有效改善临床症状,改善炎症指标,缓解疼痛.%Objective To study the effect of Shaoyao Gancao decoction on the serum levels of IL-1β, TNF-α, and pain in patients with dysmenorrhea. Methods 116 cases of dysmenorrhea patients in our hospital were treated from May 2014 to May 2016 and divided into experimental group and control group (n=58) according to the treatment methods, the control group was treated with conventional medicine, and the experimental group was treated with peony and Licorice Decoction on the basis of the control group for 4 months, the clinical symptoms, serum IL-1β, TNF-α and pain scores were observed in the two groups. Results The total effective rate of the experimental group (98.3%) was significantly higher than the control group (79.3%) (P<0.05); The serum levels of TNF-α, IL-1β of experimental group was significantly better than the control group (P<0.05); The pain score of experimental group was significantly less than the control group (P<0.05). Conclusion Shaoyao Gancao decoction in the treatment of dysmenorrhea patients can effectively improve the symptoms of patients and reduce inflammatory markers and pain.