Objective To investigate the relationship between ischemic stroke and abnormal lipid metabolism in young patients ,and evaluate its risk factors .Methods We evaluated the level of lipid ,blood glucose , blood pressure and others in 56 young patients with ischemic stroke ,52 age-matched young healthy controls ,59 elderly patients with ischemic stroke and 54 age-matched elder healthy controls .Results The level of total cholesterol(TC),triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C)in young patients with ischemic stroke was higher than that in young control group ( P <0.05 ) .The level of high density lipoprotein-cholesterol ( HDL-C) and apolipoprotein A ( Apo-A) was lower than that in young control group and elderly group with ischemic stroke( P<0.05).Conclusion The abnormal lipid metabolism is the major factor of ischemic stroke in young patients,and the reduction of HDL-C is probably the most important risk factor of ischemic stroke .%目的:探讨青年缺血性脑卒中与血脂代谢异常之间的关系,并评价其危险因素。方法对56例青年缺血性脑卒中患者、52例年龄匹配的青年健康对照组;59例老年缺血性脑卒中患者、54例年龄匹配的老年健康对照组的血脂、血糖及血压等指标进行分析。结果青年缺血性脑卒中患者的总胆固醇( TC )、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)含量显著高于青年对照组( P <0.05);高密度脂蛋白胆固醇( HDL-C)、载脂蛋白A含量低于青年对照组( P<0.05)及老年缺血性脑卒中组( P<0.05)。结论脂质代谢异常是引起青年缺血性脑卒中的主要因素之一,其中HDL-C降低可能是缺血性脑卒中最重要的危险因素。
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