COMT 基因多态性与颅脑创伤患者执行功能障碍相关性的研究

摘要

目的：探讨儿茶酚胺氧位甲基转移酶（ COMT）基因多态性与颅脑创伤患者执行功能障碍的相关性。方法选取河北联合大学神经外科颅脑创伤患者168例为病例组和134例健康体检人群为对照组。采集患者静脉血检测COMT基因多态性，应用钟表绘画测验（ CDT）、威斯康星卡片测验系统（ WCST）对患者进行执行功能评估。结果正常对照组和病例组COMT基因型及等位基因频率之间分布差异无统计学意义（ P＞0．05）；不同教育程度、损伤部位、损伤类型及有无饮酒的颅脑创伤患者间COMT基因型和等位基因频率差异无统计学意义（ P＞0．05）；不同病情程度颅脑创伤患者间COMT基因型差异有统计学意义（ P＞0．05），而等位基因频率差异无统计学意义（ P＞0．05）。 WCST评测显示携带G／G基因型颅脑创伤患者的完成分类数（CC）分值低于携带GA＋AA基因型患者；而持续性错误数（RPE）、完成第一个分类所需应答数（RF）分值高于携带GA＋AA基因型颅脑创伤患者（ P＜0．05）。结论 COMT G／G基因型与颅脑创伤患者执行功能障碍有一定关系，可能是颅脑创伤患者执行功能损伤的风险。%Objective To explore the correlation between COMT allele gene and executive dysfunction in patientswithcraniocerebraltrauma.Methods 168casesofpatientswithcraniocerebraltrauma(fromneurosurgery department of the Affiliated Hospital , Hebei United University ) as case group and 134 cases of regular physical examination as control group.COMT gene polymorphism was detected with polymerase chain reaction ( PCR ) techeqich;the executive function was evaluated with the Clock Drawing Test ( CDT) and Wisconsin Card Sorting Test ( WCST) .Results There were no difference in COMT genotype and allele frequency between case group and control group( P>0.05) .There were no difference in COMT genotype and allele frequency among the craniocerebral trauma patients of different education level, injury site, injury type and drinking or not; There was difference in COMT genotype between different severity craniocerebral trauma patients( P<0.05) ,while no difference in allele frequency( P>0.05) .WCST results showed that the CC scores of Those who carry G/G allele were lower than those carry GA+AA allele,while RPE scores and RF scores higher those carry GA+AA allele.( P<0.05) .Conclusion The genotype G/G can increase the risk of injury of executive function impairment in patients with craniocerebral trauma.