超声造影在乳腺癌前哨淋巴结显像中的应用价值研究

摘要

目的:探讨经皮下注射超声造影剂(Sonovue)探测乳腺癌腋窝前哨淋巴结(SLN)的显像成功率.方法:术前对26例乳腺癌患者行超声检查,在乳腺肿块周边(分别在12、3、6、9点钟位置)经皮下注射造影剂(SonoVue)共1.0 ml,按摩5 min,通过造影剂在淋巴管中实时显像寻找造影剂到达的第一个或数个淋巴结,即超声判定SLN,予以定位,术中单独分离,再行腋窝淋巴结清扫,术后将SLN与其他腋窝淋巴结分别行病理检查,根据病理结果评估超声造影探测的SLN是否是临床真正的SLN,分析SLN显像成功率.结果:23例患者腋窝SLN可显示,后根据病理结果判定23例超声造影探测的SLN中22例是临床真正的SLN,显像成功率为84.62%(22/26).结论:经皮下组织内注射超声造影剂检查可显示淋巴管和淋巴结,其可能成为一种新的探测乳腺癌腋窝前哨淋巴结的方法.%Objective: To investigate the success rate of ultrasound imaging in axillary sentinel limpth node ( SLNs) detection by subcutaneous injection of ultrasound contrast agents. Methods : The ultrasonography were performed in 26 patients with breast cancer, and l. 0 ml of ultrasound contrast agent were injected subcutaneously around hreast tumors ( at 12,3 ,6 ,9 o' clock position ) with the microbubbles of SonoVue. The nodes were considered as SLNs and positioned when the contrast agents were found in one or numbers of lymph nodes by real-time imaging. The SLNs were isolate and dissected during the surgery , and the success rates of ultrasound imaging were evaluate according to the pathological examination. Results : In all patients, the SLNs were detected in 23 cases, and 22 cases of them were confirmed by pathological examination,the success rate of ultrasound imaging was 84. 62％ ( 22/26 ) . Conclusions : Contrastenhanced ultrasonography may be a useful method for SLNs detection.