系统性红斑狼疮患者外周血浆细胞样树突状细胞的变化及意义

摘要

目的：：探讨系统性红斑狼疮( SLE)患者外周血中浆细胞样树突状细胞( pDC)及干扰素-α( INF-α)水平的变化及意义。方法：选取SLE患者60例( SLE组)和正常健康人30名(对照组),利用流式细胞术检测外周血pDC在各组的相对计数；ELISA法测定血清中INF-α的浓度。结果：SLE患者外周血pDC相对计数显著低于对照组(P0.05)。肾脏病变阳性组的SLE患者外周血pDC相对计数低于阴性组患者(P0.05)。 SLE患者外周血pDC相对计数与红细胞沉降率、C反应蛋白、免疫球蛋白G、免疫球蛋白A、补体3、补体4及系统性红斑狼疮疾病活动度评分均无相关关系(P>0.05)。 SLE患者血清中IFN-α水平均显著高于对照组(P0. 05). The relative amount of pDC in peripheral blood in SLE patients with positive renal lesion was lower that in SLE patients with negative renal lesion(P0. 05). The relative amount of pDC in peripheral blood in SLE patients was correlation without erythrocyte sedimentation rate,C-reactive protein and immunoglobulin G and immunoglobulin,C3,C4 and activity scores of SLE( P>0. 05). The serum level of IFN-αin patients with SLE was significantly higher than that in control group(P<0. 01). Conclusions:The relative count of pDC in peripheral blood of SLE patients significantly decreases, which is correlation with disease, and a reference in clinical judgment of SLE disease activity.