慢性阻塞性肺疾病急性发作期合并糖尿病病人血流变指标及凝血纤溶功能的变化

摘要

Objective:To explore the changes of hemorheology and coagulation fibrinolysis function in acute episode chronic occlusive pulmonary disease ( AECOPD ) patients complicated with diabetes mellitus. Methods:Fifty-two AECOPD patients complicated with diabetes mellitus,50 AECOPD patients and 40 healthy people were divided into the observation group,control group and normal group, respectively. The hemorheology indexes, four routine coagulation indexes, antithrombin-Ⅲ( AT-Ⅲ) , D dimer ( D-D ) and fibrinogen degradation products( FDP) in three groups were detected. Results:The levels of whole blood viscosity,plasm viscosity,hematocrit and erythrocyte sedimentation rate in control group and observation group were significantly higher than those in normal group(P<0. 01). The hemorheology indexes in observation group were significantly higher than that in control group(P < 0. 01). The coagulase coagulation time,prothrombin time and partial thrombin time in control group and observation group were significantly less than those in normal group(P<0. 01),and the levels of fibrinogen,D-D and FDP in observation group were significantly higher than those in control group(P<0. 01),and the coagulase coagulation time in observation group was significantly less than that in normal group(P<0. 05). Conclusions:The hemorheology, and coagulation fibrinolysis function in AECOPD patients complicated with diabetes mellitus are obviously abnormal.%目的:探讨慢性阻塞性肺疾病急性发作期(AECOPD)合并糖尿病病人的血流变指标及凝血纤溶功能的变化.方法:研究纳入52例AECOPD合并糖尿病病人(观察组),50例单纯AECOPD病人(对照组)和40名健康人(正常组),测定血流变指标、凝血四项、抗凝血酶Ⅲ、D-二聚体(D-D)和纤维蛋白原降解产物(FDP).结果:对照组和观察组的全血黏度、血浆黏度、血细胞比容和红细胞沉降率增高均显著高于正常组(P<0.01);观察组各项血流变指标均显著高于对照组(P<0.01).对照组和观察组凝血纤溶功能凝血酶凝固时间、凝血酶原时间、部分凝血活酶时间显著小于正常组(P<0.01),纤维蛋白原、抗凝血酶Ⅲ、D-D、FDP均显著高于正常组(P<0.01);观察组纤维蛋白原、D-D、FDP显著高于对照组(P<0.01),凝血酶凝固时间显著小于对照组(P<0.05).结论:AECOPD合并糖尿病病人的血流变指标及凝血纤溶功能存在明显异常.