全身热疗联合化疗治疗晚期胃癌的疗效分析

摘要

Objective ToobservetheeffectandtoxicitiesofwholebodyhyperthermiacombinedwithDCFregi-menchemotherapyinthetreatmentofpatientswithadvancedgastriccancer.Methods Sixty-sevenpatientswith advanced gastric cancer were randomly divided into two groups. Thirty-two patients of the treatment group was trea-ted by DCF regimen combining with whole body hyperthermia on the first day,and 35 patients of the control group wastreatedwithDCFregimenalone.Results Theresponserateandqualityoflifeinthetreatmentgroupwerebet-ter than those in the control group(P<0. 05). There was no statistical difference in the toxicities between the two groups(P>0.05).Conclusion WholebodyhyperthermiacanenhancetheeffectofDCFregimenchemotherapy for patients with advanced gastric cancer,improve the quality of life,do not increase the toxicities of chemotherapy.%目的：观察全身热疗联合DCF方案化疗治疗晚期胃癌的近期疗效及毒副反应。方法67例晚期胃癌患者随机分为治疗组（32例）和对照组（35例），2组患者均采用DCF方案全身化疗，化疗第1天在全麻状态下用ET-SPACE全身热疗系统进行全身加热时开始静脉给药。结果治疗组总有效率和生活质量提高率均高于对照组（P均<0.05）；2组毒副反应发生率比较差异无统计学意义（P均>0.05）。结论全身热疗联合DCF方案化疗治疗晚期胃癌可以获得较好的近期疗效，改善患者的生活质量，且毒副反应未增加，值得临床进一步推广。