GP方案联合三维适形放疗同步治疗局部晚期非小细胞肺癌

摘要

目的：探讨GP方案联合三维适形放疗同步治疗局部晚期非小细胞肺癌（ NSCLC）的近期疗效和毒副反应。方法30例局部晚期NSCLC患者采用GP方案联合三维适形放疗同步治疗。结果30例患者均完成治疗计划，肺原发灶及纵隔转移淋巴结总有效率分别为83.4%和88.5%；毒副反应主要是骨髓抑制，胃肠道反应，轻中度放射性食管炎、放射性肺炎。结论 GP方案联合三维适形放疗同步治疗局部晚期NSCLC具有较好近期疗效及耐受性。%Objective To explore clinical short-term effect and toxicities of GP regimen chemotherapy combined with three dimensional conformal radiotherapy in the treatment of locally advanced non-small cell lung cancer ( NSCLC). Methods Thirty patients with locally advanced NSCLC were treated with GP regimen chemotherapy combined with three dimensional conformal radiotherapy. Results The overall response rate was 83. 4% for primary tumor,and 88. 5% for metastatic mediastinal lymph nodes. The toxicities were mostly bone marrow suppression,gas-trointestinal reaction,radiation-induced esophagitis and pneumonitis with good tolerance,which were well tolerated by patients. Conclusion GP regimen combined with three dimensional conformal radiotherapy is effect and well tol-erated in the patients with locally advanced NSCLC.