Objective To understand and analyze the prognosis of patients infected by carbapenem -resistant Pseud-omonas aeruginosa ( PA) in ICU so as to provide a reliable basis for clinical treatment .Methods A total of 126 strains of PA were identified an their source distribution was analyzed .These strains were derived from bacterial cultures collect-ed in ICU of my hospital between Jan 2010 and Dec 2012;the identification of bacteria was completed by using ATB mi-crobial identification system of semi automatic .The drug susceptibility testing was carried out using Kirby -Bauer meth-od;78 patients infected by PA were divided into carbapenem -resistant patient group and non -carbapenem -resistant patient group.For both groups, the fatality rate, ICU staying and the duration of using of ventilator were ana-lyzed.Results The PA strains derived from the sputum were the predominant , accounting for 57.14%of the total num-ber, followed by the drainage fluid (21.43%), blood(15.08%), the tip of catheter (3.17%), puncture fluid and wound secretion were the same ( 1.59%) .The resistant rates of PA to imipenem and meropenem were 31.45% and 25.29%respectively.As compared with the non carbapenem -resistant patient group , the prognosis of the patients with PA infection was poor and the fatality rate was high , reaching up to 78.57%;the difference was statistically significant ( P<0.05 ) , the duration of ICU staying and using of ventilator were extended , the difference was statistically significant (P<0.05).Conclusions For patients infected by PA in ICU, the bacterial resistance is serious, the fatality rate is high , the prognosis is poor .We must use antimicrobial drugs reasonably and monitor bacterial resistance vigorously in Clinical treatment.%目的：了解ICU耐碳青霉烯类铜绿假单胞菌感染患者的耐药情况，并作出分析，为临床预防及治疗提供可靠依据。方法收集2010年1月～2012年12月ICU经细菌培养鉴定为铜绿假单胞菌菌株126株，采用ATB微生物半自动鉴定系统进行细菌鉴定，用Kirby-Bauer纸片扩散法进行药物敏感性试验。将铜绿假单胞菌感染患者78例经药敏试验分为耐碳青霉烯类患者组和非耐药组，对两组患者的病死率、入住ICU天数及带呼吸机天数进行分析。结果从痰液中分离出的铜绿假单胞菌菌株占首位，为57．14％，其余依次为引流液21．43％，血液15．08％，导管尖端3．17％，穿刺液和伤口分泌物均是1．59％；铜绿假单胞菌对亚胺培南、美罗培南的耐药率分别是31．45％和25．29％；与非耐药组比较，耐药组患者的预后差、病死率高，达到78．57％（ P＜0．05）；患者入住ICU天数延长和带天数均较非耐药组有显著差异（ P＜0．05）。结论 ICU中耐青霉烯类铜绿假单胞菌感染患者耐药情况严重，病死率高，预后差。临床治疗中要合理使用抗菌药物，加强细菌耐药的监测。
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