清热化痰法治疗慢性阻塞性肺疾病急性加重痰热郁（蕴）肺证研究进展

摘要

Objective To summary the research progress of clearing heat and resolving phlegm in treating AECOPD syndrome of phlegm - heat obstructing lung. Methods Analysis the clinical and experiment research of clearing heat and resolving phlegm in treating AECOPD syndrome of phlegm-heat obstructing lung in recent years. Results TCM holds that the disease belong to the category of“ lung expansion”,during the acute exacerbation the syndrome of phlegm-heat obstructing lung appears more,the decoction of Chinese medicine and the Chinese patent drugs in the treatment of AECOPD syndrome of phlegm-heat obstructing lung have a better effect. Conclusion The method of clearing heat and resolving phlegm in treating AECOPD syndrome of phlegm - heat obstructing lung reduce high air-way mucus secretion,inhibit inflammation response;have effect of antibiotics;inhibition of oxidative stress.%目的：总结近年来清热化痰法治疗 AECOPD 痰热郁肺证的研究进展。方法对近年来运用清热化痰法治疗 AECOPD 痰热郁肺证的临床及实验研究报道进行总结分析。结果在中医药理论指导下，认为COPD 属于“肺胀”范畴，急性加重期痰热郁肺证较为多见，运用具有清热化痰作用的中药汤剂及中成药治疗AECOPD 痰热郁肺证均有较好疗效。结论清热化痰法治疗 AECOPD 痰热郁肺证作用机制：减轻气道黏液高分泌，抑制炎症反应；对抗生素的增效作用；抑制氧化应激。